Adipose Tissue (BAT):
is brown fat (scientists call it fat adipose tissue).
You don't have much of it. BAT is found in very
small amounts throughout the body. You can't see
it on you. It is GOOD FAT. You want all of this
kind of fat you can get. BAT has only one purpose
- to create heat. To do that, it must use calories.
Where does it get the calories to burn? From white
fat (White Adipose Tissue). White fat is BAD FAT;
the fat you can see on your body; the fat you
want to get rid of!
- How does it work?
Thermogenesis is the term used by scientists
to describe the activity of BAT, which includes
dozens of biochemical and metabolic events. The
basic outcome of these events is the generation
of thermo units, in other words, the creation
of heat in your body. But there is a hitch, as
you will see in a moment.
has been observed in living organisms in the following
In Hibernating Animals- Ever
wonder why hibernating animals don't freeze to death?
The answer is thermogenesis. Their bodies spend all
winter burning up stored white fat. The burning is done
in BAT and it generates enough heat to keep the animal
In Cold Adaptation- Ever seen
someone working outside in freezing weather with nothing
on his/her upper body but a T-shirt? They can do this
because they have "adapted" to the cold. And
how did this adaptation take place? The same way it
did with the hibernating animal. The cold-activated
thermogenesis in the BAT.
- In Eating- Thermogenesis occurs following meals.
Unfortunately, most of the calories are supplied directly
by the food, not by the white fat.
- In Small Children- It seems that small children
have considerable BAT. However, as they get older, the
amount of BAT gradually decreases until, as adults, they
have very little. One of the problems facing scientists
was to explain this process.
hitch, then, is simply this: Under normal every-day
circumstances, people have little capacity for
thermogenesis. Living in warm climates, heated
homes and cars, and modern eating behaviors and
stresses have all seriously suppressed thermogenic
capacity. However, scientists have discovered
how to reverse the process that strips us of our
thermogenic capacity as we leave childhood, or
to give us the thermogenesis that we might never
have possessed (due to hereditary factors). Thin & Slim Naturally
is based on this research. Since 1992, Thin
& Slim Naturally has been proven to be
one of the most effective thermogenic products
on the market. The key to Thin & Slim
Naturally is to generate as much BAT activity
as possible, and in many cases even reactivate
BAT that has gone completely dormant or has become
less effective as we age.
Around the World Lead the Way:
Canadian scientists have been
involved in thermogenic research for a number
of years. The mechanism underlying cold adaptation
would, of course, be of interest to dwellers in
this northern country. Writing from the University
of Alberta in Edmonton, Paul Trayhurn explains:
the past decade, views on the function of Brown
Adipose Tissue (BAT) have undergone a fundamental
revision. This has been accompanied by a major
change in our perspective on energy balance
and its regulation. BAT is the only tissue in
mammals in which heat is the primary product
of metabolism. The tissue has traditionally
been considered to be important in the generation
of heat by non-shivering mechanisms in the newborn
or a number of mammalian species, and to play
a key role in the arousal of hibernating animals.
Within the past decade, it has also been shown
to be the main site of non-shivering thermogenesis
in adult rodents adapted to the cold. From this,
the concept has developed that BAT plays a major
role in energetics."
(Int'l Jour. of Obesity, 4(Suppl. 1), 17-29,
scientists were trying to understand and explain
the concept of thermogenesis, it occurred to them
that continued BAT activation in people might lead
to a reduction in white fat. For years, however,
it was an accepted fact that adult humans did not
have enough BAT to burn enough calories to make
a difference. Then the uncoupling protein (UCP)
was found. What makes the BAT cells different from
all the other cells in the body is the presence
of a small protein molecule that "uncouples"
the train of biochemical events that normally turn
calories into the kind of energy cells needed to
carry out metabolic processes. As a result, the
energy generated in BAT is simply wasted; it is
radiated away from BAT into the blood and into neighboring
tissues as heat. The discovery of the uncoupling
protein unlocked the mysteries of thermogenesis.
It was quickly discovered, for instance, that cold
adaptation occurs because the cold generates an
increase in the amount of uncoupling protein present
in BAT. The more UCP the greater the capacity for
it was found that the frequent activation of thermogenesis
resulted in an increase in the amount of BAT in
the body. More BAT, more UCP, more capacity for
thermogenesis. Maybe adult humans DID have enough
BAT to make a difference; or, if not, they could
acquire it. M.J. Stock, of the University of London,
wrote the following regarding this discovery:
to the high thermogenic capacity, BAT, even
in very small quantities, such as those found
in an adult male, can significantly influence
heat production. As little as 50g of BAT could
make a contribution of 10-15% additional energy
turnover in humans. This would be more than
sufficient to cause large differences in fat
deposition between individuals with active
or inactive dietary induced thermogenesis."
(Infusionstherapie 16(6), 282-4, 1989).
scientists were postulating that some deficiency
in the body's ability to burn calories in thermogenesis
might have something to do with obesity. Genetic,
environmental and dietary factors were investigated.
It was determined that the body unable to burn calories
as heat stores them in white fat. For example, Arene
Astrup of the University of Copenhagen in Denmark,
one of the pioneering researchers in thermogenesis,
a number of obesity syndromes in rodents,
the sympathetic mediation (of thermogenesis)
is defective, and this leads to extreme sensitivity
to cold and to obesity... Likewise, the hypothesis
has been advanced that a diminished thermogenesis
in BAT may be the cause of some human obesity."
(Acta Endocrinology, Suppl. 278, 1-32, 1986).
Astrup's hypothesis led to a flurry
of research on this topic, especially those medical
institutions associated with Harvard University.
Of major impact to countless humans are findings
that genetic defects in thermogenic capacity can
sometimes be totally reversed by ingesting the
correct substances. Thin & Slim Naturally
is a reflection of those findings. The Harvard
findings demonstrate that in the fa/fa rat
(a genetically obese rat) a mixture of (substances
that activate thermogenesis) reduces food
intake but also minimizes the fall in metabolic
rate that usually accompanies such an energy
deficit, effects that led to a reversal of
their gross obesity."
(Journal of Nutrition 117(2), 383-9, 1987).
studies indicate that, unlike food restriction,
the (thermogenic) mixture prevents or arrests
the development of obesity in the fa/fa mutant
by normalizing their energetic efficiency
to that of the lean."
(American Journal of Physiology 252(3 Pt 2),
that Activate Thermogenesis:
it was decided that adult humans did have the
capacity for weight management based on thermogenesis,
the hunt was on for dietary substances that could
activate BAT in humans. It was readily accepted
that all foods would activate BAT in some small
degree and that the calories would be acquired
almost entirely from the food itself; therefore,
stronger agents were sought. These agents would
have to have little or no calories in and of themselves,
but they would have to chemically activate BAT.
Again, Harvard scientists have led the way. Though
researchers in Canada, England, Australia and
other countries have all contributed to our understanding
of BAT physiology, the Harvard Group always seems
to address the questions of most relevance to
humans seeking weight loss management tools. Ongoing
research there continues to demonstrate the efficacy
of thermogenic agents in reducing stores of white
fat in overweight humans. (See, for example, Dulloo,
A.G. & Miller, D.S. International Journal
of Obesity, 467-81, 1986).
As often happens in the history of medical science,
the tightly controlled, experimental research
of orthodox medicine and the loosely observed
procedures of traditional medicine merged toward
a common understanding of how pharmaceutical agents
could have a major impact on weight management.
On the orthodox side, the same strong drugs used
to activate BAT in animals have also been used
in humans. On the traditional side, an inspection
of the literature shows that mild-acting herbs
have also been used to manage weight, but without
any understanding of BAT or UCP or even thermogenesis.
Thin & Slim Naturally was developed from
the rather startling observation that the thermogenic
drugs of orthodox medicine were derived directly
from the thermogenic herbs of traditional medicine!
reasoning behind Thin
& Slim Naturally
USE DRUGS WITH THEIR RISKY SIDE EFFECTS WHEN YOU
CAN USE NATURAL ALTERNATIVES,
in which the active principles are found together
with other inherent synergistic principles THAT
HELP TO PREVENT SIDE EFFECTS?"
Which would you rather have? The developers of
Thin & Slim Naturally
are confident that most people, given the
choice, will select the safe and natural way.
of synergy, one of the most striking features
of the research on thermogenesis was the finding
that the major thermogenic agents work best when
combined together. This is important since it
means that smaller quantities of each individual
agent need to be ingested. What the research on
thermogenesis has provided is the rationale for
bringing them together in one product. Daniel
Mowrey, Ph.D., Director of the American Phytotherapy
Research Laboratory in Salt Lake City, Utah, who
has spear-headed the use of herbs in the activation
of thermogenesis, writes:
new, drug-oriented approach to weight management
(in people without a history of heart disease
or hypertension) through the activation of
[the] primitive, semi-latent, thermogenic
mechanism, has its roots squarely in the realm
of traditional herbal medicine-- the drugs
are simply isolated, concentrated, sometimes
synthetic, derivatives of certain plant constituents.
What we have observed, however, is that the
use of the original herbal material obtains
the same thermogenic results as the drugs;
the advantage of using the herbs is, of course,
the dramatically reduced risk of significant
side effects. The active plant constituents,
buffered by the presence of the other constituents
in the plants themselves, are better suited
for the human constitution than are purified
drugs. The natural approach is still the best."
(Effective Weight Management Through Natural
Thermogenesis- Keats Publishing, in press;
quote used with permission of author.)
All This Means to You
& Slim Naturally is your chance
to take advantage of this amazing and revolutionary
approach to weight management. Consider these
Thermogenesis: When activated
by Thin & Slim
Naturally, thermogenesis does not require
any other form of dietary management or exercise.
In fact, there is some evidence that exercise, if done
within an hour of ingesting thermogenic compounds, will
tend to inhibit thermogenesis in BAT. Watching what
you eat, though not as critical as in other diet plans,
is still a sensible idea.
Increased Energy: Because thermogenic
herbs also increase the flow of blood to muscle tissue,
you experience an increase in nutrient and oxygen supply
to those tissues which translates into greater capacity
for work and exercise. In spite of what it says above
about exercise, people are still losing weight even
if they work hard and exercise immediately following
the ingestion of thermogenic herbs. Perhaps the natural
holistic materials, being a composite of hundreds of
natural constituents, provide a better basis for normal
and healthy living than do drugs.
Anti-Asthma / Anti-Hayfever Effects:
One of the beneficial "side-effects" of several
of the thermogenic herbs is a well-documented ability
to prevent asthma attacks, dry up the sinuses, reduce
the frequency and severity of hayfever episodes, and
offer relief from some allergies.
Much Smaller Chance of Side Effects:
This natural alternative is much safer than drugs. As
one authority wrote in reviewing the status of thermogenic
"Various groups of drugs have been tried, such
as amphetamine derivatives, adrenergic drugs, serotonin
agonist or hormones with thermogenic effects, intestinal
enzyme inhibitors and dietary fibre. The results of
sympathomimetic drugs demonstrate a relatively high
incidence of side-effects, and with some preparations
there is a risk of addiction."
(U. Keller, Ther.Unsch. 47(8), 658-63, 1990, in German.)
- Increasing Capacity Over Time: Since capacity
for thermogenesis depends on the amount of uncoupling
protein and the amount of brown fat, and since those substances
increase over time as the thermogenic herbs are used,
even people who start out experiencing very little effect
will increase their capacity if they consistently use
Thin & Slim Naturally
Appetite Suppression: Another
beneficial "side-effect" of thermogenic herbs
is a decrease in sensations of hunger, a welcome feeling
for people prone to eating frequently or heavily. In
1991, Astrup wrote, "The ideal anti-obesity drug
possesses anorectic (appetite suppressing), as well
as thermogenic properties without having serious side-effects."
He could have found such agents by switching his focus
from drugs to raw plant materials.
statements herein have not been evaluated by the
FDA, and are intended for educational purposes only.
These products are not intended to treat, diagnose,
cure , mitigate or prevent any disease. If you have
a serious medical condition, consult with your doctor