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THERMOGENIC
WEIGHT LOSS
Brown
Adipose Tissue (BAT):
BAT
is brown fat (scientists call it fat adipose
tissue). You don't have much of it. BAT is found
in very small amounts throughout the body. You
can't see it on you. It is GOOD FAT. You want
all of this kind of fat you can get. BAT has
only one purpose - to create heat. To do that,
it must use calories. Where does it get the
calories to burn? From white fat (White Adipose
Tissue). White fat is BAD FAT; the fat you can
see on your body; the fat you want to get rid
of!
Thermogenesis
- How does it work?
Thermogenesis is the term used by scientists
to describe the activity of BAT, which includes
dozens of biochemical and metabolic events.
The basic outcome of these events is the generation
of thermo units, in other words, the creation
of heat in your body. But there is a hitch,
as you will see in a moment.
Thermogenesis
has been observed in living organisms in the
following natural situations:
-
In
Hibernating Animals- Ever wonder why hibernating
animals don't freeze to death? The answer is thermogenesis.
Their bodies spend all winter burning up stored white
fat. The burning is done in BAT and it generates enough
heat to keep the animal warm.
-
In
Cold Adaptation- Ever seen someone working outside
in freezing weather with nothing on his/her upper body
but a T-shirt? They can do this because they have "adapted"
to the cold. And how did this adaptation take place?
The same way it did with the hibernating animal. The
cold-activated thermogenesis in the BAT.
-
In Eating- Thermogenesis occurs following meals. Unfortunately,
most of the calories are supplied directly by the food,
not by the white fat.
-
In Small Children- It seems that small children have
considerable BAT. However, as they get older, the amount
of BAT gradually decreases until, as adults, they have
very little. One of the problems facing scientists was
to explain this process.
The
hitch, then, is simply this: Under normal
every-day circumstances, people have little
capacity for thermogenesis. Living in warm
climates, heated homes and cars, and modern
eating behaviors and stresses have all seriously
suppressed thermogenic capacity. However, scientists
have discovered how to reverse the process that
strips us of our thermogenic capacity as we
leave childhood, or to give us the thermogenesis
that we might never have possessed (due to hereditary
factors). Thin & Slim Naturally
is based on this research. Since 1992, Thin
& Slim Naturally has been proven to
be one of the most effective thermogenic products
on the market. The key to Thin & Slim
Naturally is to generate as much BAT activity
as possible, and in many cases even reactivate
BAT that has gone completely dormant or has
become less effective as we age.
Universities
Around the World Lead the Way:
Canadian scientists have been
involved in thermogenic research for a number
of years. The mechanism underlying cold adaptation
would, of course, be of interest to dwellers
in this northern country. Writing from the University
of Alberta in Edmonton, Paul Trayhurn explains:
"In
the past decade, views on the function of
Brown Adipose Tissue (BAT) have undergone
a fundamental revision. This has been accompanied
by a major change in our perspective on energy
balance and its regulation. BAT is the only
tissue in mammals in which heat is the primary
product of metabolism. The tissue has traditionally
been considered to be important in the generation
of heat by non-shivering mechanisms in the
newborn or a number of mammalian species,
and to play a key role in the arousal of hibernating
animals. Within the past decade, it has also
been shown to be the main site of non-shivering
thermogenesis in adult rodents adapted to
the cold. From this, the concept has developed
that BAT plays a major role in energetics."
(Int'l Jour. of Obesity, 4(Suppl. 1), 17-29,
1990).
While
scientists were trying to understand and explain
the concept of thermogenesis, it occurred to them
that continued BAT activation in people might lead
to a reduction in white fat. For years, however,
it was an accepted fact that adult humans did not
have enough BAT to burn enough calories to make
a difference. Then the uncoupling protein (UCP)
was found. What makes the BAT cells different from
all the other cells in the body is the presence
of a small protein molecule that "uncouples"
the train of biochemical events that normally turn
calories into the kind of energy cells needed to
carry out metabolic processes. As a result, the
energy generated in BAT is simply wasted; it is
radiated away from BAT into the blood and into neighboring
tissues as heat. The discovery of the uncoupling
protein unlocked the mysteries of thermogenesis.
It was quickly discovered, for instance, that cold
adaptation occurs because the cold generates an
increase in the amount of uncoupling protein present
in BAT. The more UCP the greater the capacity for
thermogenesis.
Next
it was found that the frequent activation of
thermogenesis resulted in an increase in the
amount of BAT in the body. More BAT, more UCP,
more capacity for thermogenesis. Maybe adult
humans DID have enough BAT to make a difference;
or, if not, they could acquire it. M.J. Stock,
of the University of London, wrote the following
regarding this discovery:
"Due
to the high thermogenic capacity, BAT, even
in very small quantities, such as those
found in an adult male, can significantly
influence heat production. As little as
50g of BAT could make a contribution of
10-15% additional energy turnover in humans.
This would be more than sufficient to cause
large differences in fat deposition between
individuals with active or inactive dietary
induced thermogenesis."
(Infusionstherapie 16(6), 282-4, 1989).
Meanwhile,
scientists were postulating that some deficiency
in the body's ability to burn calories in thermogenesis
might have something to do with obesity. Genetic,
environmental and dietary factors were investigated.
It was determined that the body unable to burn calories
as heat stores them in white fat. For example, Arene
Astrup of the University of Copenhagen in Denmark,
one of the pioneering researchers in thermogenesis,
wrote:
"In
a number of obesity syndromes in rodents,
the sympathetic mediation (of thermogenesis)
is defective, and this leads to extreme
sensitivity to cold and to obesity... Likewise,
the hypothesis has been advanced that a
diminished thermogenesis in BAT may be the
cause of some human obesity."
(Acta Endocrinology, Suppl. 278, 1-32, 1986).
The
Harvard Studies
Astrup's hypothesis led to a
flurry of research on this topic, especially
those medical institutions associated with Harvard
University. Of major impact to countless humans
are findings that genetic defects in thermogenic
capacity can sometimes be totally reversed by
ingesting the correct substances. Thin & Slim Naturally
is a reflection of those findings. The Harvard
Group reported:
"These
findings demonstrate that in the fa/fa rat
(a genetically obese rat) a mixture of (substances
that activate thermogenesis) reduces food
intake but also minimizes the fall in metabolic
rate that usually accompanies such an energy
deficit, effects that led to a reversal
of their gross obesity."
(Journal of Nutrition 117(2), 383-9, 1987).
Also
this:
"These
studies indicate that, unlike food restriction,
the (thermogenic) mixture prevents or arrests
the development of obesity in the fa/fa
mutant by normalizing their energetic efficiency
to that of the lean."
(American Journal of Physiology 252(3 Pt
2), R507-13, 1987).
Substances
that Activate Thermogenesis:
Once
it was decided that adult humans did have the
capacity for weight management based on thermogenesis,
the hunt was on for dietary substances that
could activate BAT in humans. It was readily
accepted that all foods would activate BAT in
some small degree and that the calories would
be acquired almost entirely from the food itself;
therefore, stronger agents were sought. These
agents would have to have little or no calories
in and of themselves, but they would have to
chemically activate BAT. Again, Harvard scientists
have led the way. Though researchers in Canada,
England, Australia and other countries have
all contributed to our understanding of BAT
physiology, the Harvard Group always seems to
address the questions of most relevance to humans
seeking weight loss management tools. Ongoing
research there continues to demonstrate the
efficacy of thermogenic agents in reducing stores
of white fat in overweight humans. (See, for
example, Dulloo, A.G. & Miller, D.S. International
Journal of Obesity, 467-81, 1986).
Drugs
Versus Nature
As often happens in the history of medical science,
the tightly controlled, experimental research
of orthodox medicine and the loosely observed
procedures of traditional medicine merged toward
a common understanding of how pharmaceutical
agents could have a major impact on weight management.
On the orthodox side, the same strong drugs
used to activate BAT in animals have also been
used in humans. On the traditional side, an
inspection of the literature shows that mild-acting
herbs have also been used to manage weight,
but without any understanding of BAT or UCP
or even thermogenesis. Thin & Slim Naturally was developed from
the rather startling observation that the thermogenic
drugs of orthodox medicine were derived directly
from the thermogenic herbs of traditional medicine!
Our
reasoning behind Thin
& Slim Naturally
is:
"WHY
USE DRUGS WITH THEIR RISKY SIDE EFFECTS WHEN
YOU CAN USE NATURAL ALTERNATIVES,
in which the active principles are found together
with other inherent synergistic principles THAT
HELP TO PREVENT SIDE EFFECTS?"
Which would you rather have? The developers
of Thin & Slim Naturally
are confident that most people, given the
choice, will select the safe and natural way.
Speaking
of synergy, one of the most striking features
of the research on thermogenesis was the finding
that the major thermogenic agents work best
when combined together. This is important since
it means that smaller quantities of each individual
agent need to be ingested. What the research
on thermogenesis has provided is the rationale
for bringing them together in one product. Daniel
Mowrey, Ph.D., Director of the American Phytotherapy
Research Laboratory in Salt Lake City, Utah,
who has spear-headed the use of herbs in the
activation of thermogenesis, writes:
"The
new, drug-oriented approach to weight management
(in people without a history of heart disease
or hypertension) through the activation
of [the] primitive, semi-latent, thermogenic
mechanism, has its roots squarely in the
realm of traditional herbal medicine-- the
drugs are simply isolated, concentrated,
sometimes synthetic, derivatives of certain
plant constituents. What we have observed,
however, is that the use of the original
herbal material obtains the same thermogenic
results as the drugs; the advantage of using
the herbs is, of course, the dramatically
reduced risk of significant side effects.
The active plant constituents, buffered
by the presence of the other constituents
in the plants themselves, are better suited
for the human constitution than are purified
drugs. The natural approach is still the
best."
(Effective Weight Management Through Natural
Thermogenesis- Keats Publishing, in press;
quote used with permission of author.)
What
All This Means to You
Thin
& Slim Naturally is your
chance to take advantage of this amazing and
revolutionary approach to weight management.
Consider these benefits:
-
Thermogenesis: When activated by Thin
& Slim Naturally, thermogenesis does
not require any other form of dietary management or
exercise. In fact, there is some evidence that exercise,
if done within an hour of ingesting thermogenic compounds,
will tend to inhibit thermogenesis in BAT. Watching
what you eat, though not as critical as in other diet
plans, is still a sensible idea.
-
Increased Energy: Because thermogenic herbs also
increase the flow of blood to muscle tissue, you experience
an increase in nutrient and oxygen supply to those tissues
which translates into greater capacity for work and
exercise. In spite of what it says above about exercise,
people are still losing weight even if they work hard
and exercise immediately following the ingestion of
thermogenic herbs. Perhaps the natural holistic materials,
being a composite of hundreds of natural constituents,
provide a better basis for normal and healthy living
than do drugs.
-
Anti-Asthma / Anti-Hayfever Effects: One of the
beneficial "side-effects" of several of the
thermogenic herbs is a well-documented ability to prevent
asthma attacks, dry up the sinuses, reduce the frequency
and severity of hayfever episodes, and offer relief
from some allergies.
-
Much
Smaller Chance of Side Effects: This natural alternative
is much safer than drugs. As one authority wrote in
reviewing the status of thermogenic drugs:
"Various
groups of drugs have been tried, such as amphetamine
derivatives, adrenergic drugs, serotonin agonist or
hormones with thermogenic effects, intestinal enzyme
inhibitors and dietary fibre. The results of sympathomimetic
drugs demonstrate a relatively high incidence of side-effects,
and with some preparations there is a risk of addiction."
(U. Keller, Ther.Unsch. 47(8), 658-63, 1990, in German.)
-
Increasing Capacity Over Time: Since capacity for
thermogenesis depends on the amount of uncoupling protein
and the amount of brown fat, and since those substances
increase over time as the thermogenic herbs are used,
even people who start out experiencing very little effect
will increase their capacity if they consistently use
Thin & Slim Naturally
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Appetite Suppression: Another beneficial "side-effect"
of thermogenic herbs is a decrease in sensations of
hunger, a welcome feeling for people prone to eating
frequently or heavily. In 1991, Astrup wrote, "The
ideal anti-obesity drug possesses anorectic (appetite
suppressing), as well as thermogenic properties without
having serious side-effects." He could have found
such agents by switching his focus from drugs to raw
plant materials.
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The
statements herein have not been evaluated by the
FDA, and are intended for educational purposes only.
These products are not intended to treat, diagnose,
cure , mitigate or prevent any disease. If you have
a serious medical condition, consult with your doctor
before using.
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